- "No discernible talents. Some enthusiasm for music, but mediocre skill—can hardly even hobble through a Paganini caprice. Utterly useless."
- —The Monocle[src]
Vanya Hargreeves is one of the children that Professor Hargreeves adopted in order to "save the world", whose original name was 00.07. She is considered among her siblings to be the youngest one. Unlike her brothers and sister, Vanya apparently has no power and is a common girl that according to her father can barely play the violin.
Vanya was born from a woman that had no signs of pregnancy like her siblings and was one of the few that Hargreeves found. All of the other kids Hargreeves adopted developed some kind of supernatural ability at a very young age, however Vanya was the only one that did not. Due to this, she always grew up feeling different from the rest of her family. In fact, Hargreeves never encouraged her in any way and apparently never seemed to show any interest in her.
In "The day the Eiffel tower went Berserk" she wanted to go outside but her father just told her that she could not because there was nothing she could do. In another occasion she was frustrated because she couldn't even play the violin well and ended up breaking it.
In her teenage years she went through a rebellious phase. During this time she seemed to be very connected to the Kraken and the both of them were in a punk-rock band. Still, Kraken continued as a member of the Academy. After he left the band due to a mission with the Academy, Vanya realized it just wasn't her place, leaving home without telling anyone.
Vanya was living alone and had written a book called "My life as 00.07" where she showed how she felt and all she lived during her years with the Umbrella Academy. She received a call from someone that wanted to meet her. When she went to the appointment, she met the Orchestra Verdammtem which was a sect that wanted to bring the end of the world through music, and wanted her to join them. At first she refused, but after going with her siblings during Doctor Terminal's robot attack and being rejected by Diego she came back wanting to destroy the world. However the Conductor wanted to awake her inner powers and explained her that he had read Hargreeves notes and he discovered that she was in fact the most dangerous of her siblings. Hargreeves had experimented with her so that she could not use her powers to destroy the world. After that the director washed her brain and make her awake her powers. During a performance to show her abilities she killed the Conductor and went to the academy. There she killed Pogo and destroyed Ben's statue. Later she started destroying the world with the orchestra, but the Umbrella Academy appeared to stop her. During their confrontation she cut Rumor's neck. After that, Séance appeared (possessed by Hargreeves) with an orchestra to stop her. She stopped playing and started arguing with him, saying that she was going to end the world and he called that a tantrum, which after she started crying. That's when 00.05 shot her in the head and left her half dead. Séance proceeded to use his telekinesis to stop the meteorites. After that she lost her memories about who she was and was not able to walk again.
After all that had happened, Vanya is been taken care of by her family, even though she doesn't remember them. At one point Rumor, (who is still mad at her) shows her all that she did. Vanya watches, horrified at all that she had done.
At the end of Dallas, Rumor appears hugging her trying to forgive her for what she did.